diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index bd1526e..1eff486 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -25,6 +25,20 @@ Release history
 ^^^^^^^^^^^^^^^
     ..  This extra heading level keeps the ToC from becoming unmanageably long
 
+vNext
+-----
+
+*Unreleased changes*
+
+Fixes
+~~~~~
+
+* **SparkPost:** Drop support for multiple `from_email` addresses. SparkPost has
+  started issuing a cryptic "No sending domain specified" error for this case; with
+  this fix, Anymail will now treat it as an unsupported feature.
+
+
+
 v8.1
 ----
 
diff --git a/anymail/backends/sparkpost.py b/anymail/backends/sparkpost.py
index 988cc3d..0dc7f8c 100644
--- a/anymail/backends/sparkpost.py
+++ b/anymail/backends/sparkpost.py
@@ -117,10 +117,8 @@ class SparkPostPayload(RequestsPayload):
             "recipients": [],
         }
 
-    def set_from_email_list(self, emails):
-        # SparkPost supports multiple From email addresses,
-        # as a single comma-separated string
-        self.data["content"]["from"] = ", ".join(email.address for email in emails)
+    def set_from_email(self, email):
+        self.data["content"]["from"] = email.address
 
     def set_to(self, emails):
         if emails:
diff --git a/docs/esps/sparkpost.rst b/docs/esps/sparkpost.rst
index ec5f94a..404500f 100644
--- a/docs/esps/sparkpost.rst
+++ b/docs/esps/sparkpost.rst
@@ -213,6 +213,18 @@ Limitations and quirks
   use only the domain portion and substitute its own encoded mailbox before
   the @.
 
+**Multiple from_email addresses**
+  Prior to November, 2020, SparkPost supporting sending messages with multiple
+  *From* addresses. (This is technically allowed by email specs, but many
+  ISPs bounce such messages.) Anymail v8.1 and earlier will pass multiple
+  ``from_email`` addresses to SparkPost's API.
+
+  SparkPost has since dropped support for more than one from address, and now issues
+  error code 7001 "No sending domain specified". To avoid confusion, Anymail v8.2
+  treats multiple from addresses as an unsupported feature in the SparkPost backend.
+
+  .. versionchanged:: 8.2
+
 
 .. _sparkpost-templates:
 
diff --git a/tests/test_sparkpost_backend.py b/tests/test_sparkpost_backend.py
index 3aff660..7474bc9 100644
--- a/tests/test_sparkpost_backend.py
+++ b/tests/test_sparkpost_backend.py
@@ -10,7 +10,7 @@ from django.test import override_settings, tag
 from django.utils.timezone import get_fixed_timezone, override as override_current_timezone, utc
 
 from anymail.exceptions import (
-    AnymailAPIError, AnymailConfigurationError, AnymailInvalidAddress, AnymailRecipientsRefused,
+    AnymailAPIError, AnymailConfigurationError, AnymailRecipientsRefused,
     AnymailSerializationError, AnymailUnsupportedFeature)
 from anymail.message import attach_inline_image_file
 
@@ -318,20 +318,6 @@ class SparkPostBackendStandardEmailTests(SparkPostBackendMockAPITestCase):
             },
         }])
 
-    def test_multiple_from_emails(self):
-        """SparkPost supports multiple addresses in from_email"""
-        self.message.from_email = 'first@example.com, "From, also" <second@example.com>'
-        self.message.send()
-        data = self.get_api_call_json()
-        self.assertEqual(data["content"]["from"],
-                         'first@example.com, "From, also" <second@example.com>')
-
-        # Make sure the far-more-likely scenario of a single from_email
-        # with an unquoted display-name issues a reasonable error:
-        self.message.from_email = 'Unquoted, display-name <from@example.com>'
-        with self.assertRaises(AnymailInvalidAddress):
-            self.message.send()
-
     def test_api_failure(self):
         self.set_mock_response(status_code=400)
         with self.assertRaisesMessage(AnymailAPIError, "SparkPost API response 400"):
diff --git a/tests/test_sparkpost_integration.py b/tests/test_sparkpost_integration.py
index 3d9a8d3..013c936 100644
--- a/tests/test_sparkpost_integration.py
+++ b/tests/test_sparkpost_integration.py
@@ -59,9 +59,7 @@ class SparkPostBackendIntegrationTests(AnymailTestMixin, SimpleTestCase):
         message = AnymailMessage(
             subject="Anymail all-options integration test",
             body="This is the text body",
-            # Caution: although SparkPost allows multiple From addresses,
-            # many ISPs will just bounce email that tries it...
-            from_email="Test From <test@test-sp.anymail.info>, also-from@test-sp.anymail.info",
+            from_email="Test From <test@test-sp.anymail.info>",
             to=["to1@test.sink.sparkpostmail.com", "Recipient 2 <to2@test.sink.sparkpostmail.com>"],
             # Limit the live b/cc's to avoid running through our small monthly allowance:
             # cc=["cc1@test.sink.sparkpostmail.com", "Copy 2 <cc2@test.sink.sparkpostmail.com>"],