diff --git a/.github/workflows/integration-test.yml b/.github/workflows/integration-test.yml
index f7d8768..424a0de 100644
--- a/.github/workflows/integration-test.yml
+++ b/.github/workflows/integration-test.yml
@@ -29,6 +29,7 @@ jobs:
 
   test:
     name: ${{ matrix.config.tox }} ${{ matrix.config.options }}
+    # Ubuntu 22.04 runner includes Python 3.10
     runs-on: ubuntu-22.04
     needs: skip_duplicate_runs
     if: needs.skip_duplicate_runs.outputs.should_skip != 'true'
diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index 013a8c7..d31a457 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -30,6 +30,7 @@ jobs:
           python -m tox --gh-matrix-dump  # for debugging
 
   test:
+    # Ubuntu 22.04 runner includes Python 3.10
     runs-on: ubuntu-22.04
     needs: get-envlist
     strategy:
@@ -52,7 +53,7 @@ jobs:
         # for installing/running tox
         uses: actions/setup-python@v5
         with:
-          python-version: "3.8"
+          python-version: "3.10"
       - name: Install tox
         run: |
           set -x
diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index 593dc97..d9b2bf5 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -26,6 +26,17 @@ Release history
     ..  This extra heading level keeps the ToC from becoming unmanageably long
 
 
+vNext (12.0)
+------------
+
+*unreleased changes*
+
+Breaking changes
+~~~~~~~~~~~~~~~~
+
+* Require **Django 4.0 or later** and Python 3.8 or later.
+
+
 v11.1
 -----
 
diff --git a/anymail/__init__.py b/anymail/__init__.py
index 6758502..8b9bc97 100644
--- a/anymail/__init__.py
+++ b/anymail/__init__.py
@@ -4,14 +4,3 @@ __all__ = [
     "VERSION",
     "__version__",
 ]
-
-try:
-    import django
-except ImportError:
-    # (don't require django just to get package version)
-    pass
-else:
-    if django.VERSION < (3, 2, 0):
-        # (No longer required -- and causes deprecation warning -- in Django 3.2+)
-        default_app_config = "anymail.apps.AnymailBaseConfig"
-        __all__.append("default_app_config")
diff --git a/anymail/_version.py b/anymail/_version.py
index 64c9bd9..2d5c170 100644
--- a/anymail/_version.py
+++ b/anymail/_version.py
@@ -2,6 +2,6 @@
 # Instead, load version info from the package root.
 
 #: major.minor or major.minor.patch (optionally with .devN suffix)
-__version__ = "11.1"
+__version__ = "12.0.dev0"
 
 VERSION = __version__.split(",")
diff --git a/pyproject.toml b/pyproject.toml
index be9ef7e..81c69bc 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -40,7 +40,6 @@ classifiers = [
     "Programming Language :: Python :: Implementation :: PyPy",
     "Programming Language :: Python :: Implementation :: CPython",
     "Programming Language :: Python :: 3",
-    "Programming Language :: Python :: 3.7",
     "Programming Language :: Python :: 3.8",
     "Programming Language :: Python :: 3.9",
     "Programming Language :: Python :: 3.10",
@@ -51,19 +50,17 @@ classifiers = [
     "Topic :: Software Development :: Libraries :: Python Modules",
     "Intended Audience :: Developers",
     "Framework :: Django",
-    "Framework :: Django :: 3.0",
-    "Framework :: Django :: 3.1",
-    "Framework :: Django :: 3.2",
     "Framework :: Django :: 4.0",
     "Framework :: Django :: 4.1",
     "Framework :: Django :: 4.2",
     "Framework :: Django :: 5.0",
+    "Framework :: Django :: 5.1",
     "Environment :: Web Environment",
 ]
 
 requires-python = ">=3.7"
 dependencies = [
-    "django>=2.0",
+    "django>=4.0",
     "requests>=2.4.3",
     "urllib3>=1.25.0",  # requests dependency: fixes RFC 7578 header encoding
 ]
diff --git a/tests/test_settings/settings_3_0.py b/tests/test_settings/settings_3_0.py
deleted file mode 100644
index f424a57..0000000
--- a/tests/test_settings/settings_3_0.py
+++ /dev/null
@@ -1,121 +0,0 @@
-"""
-Django settings for Anymail tests.
-
-Generated by 'django-admin startproject' using Django 3.0a1.
-
-For more information on this file, see
-https://docs.djangoproject.com/en/dev/topics/settings/
-
-For the full list of settings and their values, see
-https://docs.djangoproject.com/en/dev/ref/settings/
-"""
-
-import os
-
-# Build paths inside the project like this: os.path.join(BASE_DIR, ...)
-BASE_DIR = os.path.dirname(os.path.dirname(os.path.abspath(__file__)))
-
-
-# Quick-start development settings - unsuitable for production
-# See https://docs.djangoproject.com/en/dev/howto/deployment/checklist/
-
-# SECURITY WARNING: keep the secret key used in production secret!
-SECRET_KEY = 'NOT_FOR_PRODUCTION_USE'
-
-# SECURITY WARNING: don't run with debug turned on in production!
-DEBUG = True
-
-ALLOWED_HOSTS = []
-
-
-# Application definition
-
-INSTALLED_APPS = [
-    'django.contrib.admin',
-    'django.contrib.auth',
-    'django.contrib.contenttypes',
-    'django.contrib.sessions',
-    'django.contrib.messages',
-    'django.contrib.staticfiles',
-    'anymail',
-]
-
-MIDDLEWARE = [
-    'django.middleware.security.SecurityMiddleware',
-    'django.contrib.sessions.middleware.SessionMiddleware',
-    'django.middleware.common.CommonMiddleware',
-    'django.middleware.csrf.CsrfViewMiddleware',
-    'django.contrib.auth.middleware.AuthenticationMiddleware',
-    'django.contrib.messages.middleware.MessageMiddleware',
-    'django.middleware.clickjacking.XFrameOptionsMiddleware',
-]
-
-ROOT_URLCONF = 'tests.test_settings.urls'
-
-TEMPLATES = [
-    {
-        'BACKEND': 'django.template.backends.django.DjangoTemplates',
-        'DIRS': [],
-        'APP_DIRS': True,
-        'OPTIONS': {
-            'context_processors': [
-                'django.template.context_processors.debug',
-                'django.template.context_processors.request',
-                'django.contrib.auth.context_processors.auth',
-                'django.contrib.messages.context_processors.messages',
-            ],
-        },
-    },
-]
-
-WSGI_APPLICATION = 'tests.wsgi.application'
-
-
-# Database
-# https://docs.djangoproject.com/en/dev/ref/settings/#databases
-
-DATABASES = {
-    'default': {
-        'ENGINE': 'django.db.backends.sqlite3',
-        'NAME': os.path.join(BASE_DIR, 'db.sqlite3'),
-    }
-}
-
-
-# Password validation
-# https://docs.djangoproject.com/en/dev/ref/settings/#auth-password-validators
-
-AUTH_PASSWORD_VALIDATORS = [
-    {
-        'NAME': 'django.contrib.auth.password_validation.UserAttributeSimilarityValidator',
-    },
-    {
-        'NAME': 'django.contrib.auth.password_validation.MinimumLengthValidator',
-    },
-    {
-        'NAME': 'django.contrib.auth.password_validation.CommonPasswordValidator',
-    },
-    {
-        'NAME': 'django.contrib.auth.password_validation.NumericPasswordValidator',
-    },
-]
-
-
-# Internationalization
-# https://docs.djangoproject.com/en/dev/topics/i18n/
-
-LANGUAGE_CODE = 'en-us'
-
-TIME_ZONE = 'UTC'
-
-USE_I18N = True
-
-USE_L10N = True
-
-USE_TZ = True
-
-
-# Static files (CSS, JavaScript, Images)
-# https://docs.djangoproject.com/en/dev/howto/static-files/
-
-STATIC_URL = '/static/'
diff --git a/tests/test_settings/settings_3_1.py b/tests/test_settings/settings_3_1.py
deleted file mode 100644
index 788eba6..0000000
--- a/tests/test_settings/settings_3_1.py
+++ /dev/null
@@ -1,121 +0,0 @@
-"""
-Django settings for Anymail tests.
-
-Generated by 'django-admin startproject' using Django 3.1.
-
-For more information on this file, see
-https://docs.djangoproject.com/en/dev/topics/settings/
-
-For the full list of settings and their values, see
-https://docs.djangoproject.com/en/dev/ref/settings/
-"""
-
-import os
-
-# Build paths inside the project like this: os.path.join(BASE_DIR, ...)
-BASE_DIR = os.path.dirname(os.path.dirname(os.path.abspath(__file__)))
-
-
-# Quick-start development settings - unsuitable for production
-# See https://docs.djangoproject.com/en/dev/howto/deployment/checklist/
-
-# SECURITY WARNING: keep the secret key used in production secret!
-SECRET_KEY = 'NOT_FOR_PRODUCTION_USE'
-
-# SECURITY WARNING: don't run with debug turned on in production!
-DEBUG = True
-
-ALLOWED_HOSTS = []
-
-
-# Application definition
-
-INSTALLED_APPS = [
-    'django.contrib.admin',
-    'django.contrib.auth',
-    'django.contrib.contenttypes',
-    'django.contrib.sessions',
-    'django.contrib.messages',
-    'django.contrib.staticfiles',
-    'anymail',
-]
-
-MIDDLEWARE = [
-    'django.middleware.security.SecurityMiddleware',
-    'django.contrib.sessions.middleware.SessionMiddleware',
-    'django.middleware.common.CommonMiddleware',
-    'django.middleware.csrf.CsrfViewMiddleware',
-    'django.contrib.auth.middleware.AuthenticationMiddleware',
-    'django.contrib.messages.middleware.MessageMiddleware',
-    'django.middleware.clickjacking.XFrameOptionsMiddleware',
-]
-
-ROOT_URLCONF = 'tests.test_settings.urls'
-
-TEMPLATES = [
-    {
-        'BACKEND': 'django.template.backends.django.DjangoTemplates',
-        'DIRS': [],
-        'APP_DIRS': True,
-        'OPTIONS': {
-            'context_processors': [
-                'django.template.context_processors.debug',
-                'django.template.context_processors.request',
-                'django.contrib.auth.context_processors.auth',
-                'django.contrib.messages.context_processors.messages',
-            ],
-        },
-    },
-]
-
-WSGI_APPLICATION = 'tests.wsgi.application'
-
-
-# Database
-# https://docs.djangoproject.com/en/dev/ref/settings/#databases
-
-DATABASES = {
-    'default': {
-        'ENGINE': 'django.db.backends.sqlite3',
-        'NAME': os.path.join(BASE_DIR, 'db.sqlite3'),
-    }
-}
-
-
-# Password validation
-# https://docs.djangoproject.com/en/dev/ref/settings/#auth-password-validators
-
-AUTH_PASSWORD_VALIDATORS = [
-    {
-        'NAME': 'django.contrib.auth.password_validation.UserAttributeSimilarityValidator',
-    },
-    {
-        'NAME': 'django.contrib.auth.password_validation.MinimumLengthValidator',
-    },
-    {
-        'NAME': 'django.contrib.auth.password_validation.CommonPasswordValidator',
-    },
-    {
-        'NAME': 'django.contrib.auth.password_validation.NumericPasswordValidator',
-    },
-]
-
-
-# Internationalization
-# https://docs.djangoproject.com/en/dev/topics/i18n/
-
-LANGUAGE_CODE = 'en-us'
-
-TIME_ZONE = 'UTC'
-
-USE_I18N = True
-
-USE_L10N = True
-
-USE_TZ = True
-
-
-# Static files (CSS, JavaScript, Images)
-# https://docs.djangoproject.com/en/dev/howto/static-files/
-
-STATIC_URL = '/static/'
diff --git a/tox.ini b/tox.ini
index fa8a25f..a035676 100644
--- a/tox.ini
+++ b/tox.ini
@@ -6,7 +6,7 @@ envlist =
     # Test lint, docs, earliest/latest Django first, to catch most errors early...
     lint
     django51-py312-all
-    django30-py37-all
+    django40-py38-all
     docs
     # ... then test all the other supported combinations:
     # Django 5.1: Python 3.10, 3.11, and 3.12
@@ -18,13 +18,7 @@ envlist =
     # Django 4.1: Python 3.8, 3.9, 3.10
     django41-py{38,39,310,py38,py39}-all
     # Django 4.0: Python 3.8, 3.9, 3.10
-    django40-py{38,39,310,py38,py39}-all
-    # Django 3.2: Python 3.6 (eol 2021-12-23), 3.7, 3.8, 3.9
-    django32-py{37,38,39,py38,py39}-all
-    # Django 3.1: Python 3.6 (eol 2021-12-23), 3.7, 3.8, 3.9 (added in 3.1.3)
-    django31-py{37,38,39,py38,py39}-all
-    # Django 3.0: Python 3.6 (eol 2021-12-23), 3.7, 3.8, 3.9 (added in 3.0.11)
-    django30-py{38,39,py38,py39}-all
+    django40-py{39,310,py38,py39}-all
     # ... then prereleases (if available) and current development:
     # Django 5.2 pre-release: Python 3.10, 3.11, 3.12 and 3.13
     # django52-py{310,311,312,313}-all
@@ -41,9 +35,6 @@ args_are_paths = false
 download = true
 deps =
     -rtests/requirements.txt
-    django30: django~=3.0.0
-    django31: django~=3.1.0
-    django32: django~=3.2.0
     django40: django~=4.0.0
     django41: django~=4.1.0
     django42: django~=4.2.0