diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index f771ee6..e679b1a 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -33,6 +33,11 @@ vNext
 Fixes
 ~~~~~
 
+* **Amazon SES:** Support receiving and tracking mail in non-default (or multiple)
+  AWS regions. Anymail now always confirms an SNS subscription in the region where
+  the SNS topic exists, which may be different from the boto3 default. (Thanks to
+  `@mark-mishyn`_ for reporting this.)
+
 * **Postmark:** Fix two different errors when sending with a template but no merge
   data. (Thanks to `@kareemcoding`_ and `@Tobeyforce`_ for reporting them.)
 
@@ -1230,6 +1235,7 @@ Features
 .. _@kika115: https://github.com/kika115
 .. _@Lekensteyn: https://github.com/Lekensteyn
 .. _@lewistaylor: https://github.com/lewistaylor
+.. _@mark-mishyn: https://github.com/mark-mishyn
 .. _@mbk-ok: https://github.com/mbk-ok
 .. _@mwheels: https://github.com/mwheels
 .. _@nuschk: https://github.com/nuschk
diff --git a/anymail/webhooks/amazon_ses.py b/anymail/webhooks/amazon_ses.py
index d284493..6bd4300 100644
--- a/anymail/webhooks/amazon_ses.py
+++ b/anymail/webhooks/amazon_ses.py
@@ -130,9 +130,20 @@ class AmazonSESBaseWebhookView(AnymailBaseWebhookView):
 
         # WEBHOOK_SECRET *is* set, so the request's basic auth has been verified by now (in run_validators).
         # We're good to confirm...
-        sns_client = boto3.session.Session(**self.session_params).client('sns', **self.client_params)
+        topic_arn = sns_message["TopicArn"]
+        token = sns_message["Token"]
+
+        # Must confirm in TopicArn's own region (which may be different from the default)
+        try:
+            (_arn_tag, _partition, _service, region, _account, _resource) = topic_arn.split(":", maxsplit=6)
+        except (TypeError, ValueError):
+            raise ValueError("Invalid ARN format '{topic_arn!s}'".format(topic_arn=topic_arn))
+        client_params = self.client_params.copy()
+        client_params["region_name"] = region
+
+        sns_client = boto3.session.Session(**self.session_params).client('sns', **client_params)
         sns_client.confirm_subscription(
-            TopicArn=sns_message["TopicArn"], Token=sns_message["Token"], AuthenticateOnUnsubscribe='true')
+            TopicArn=topic_arn, Token=token, AuthenticateOnUnsubscribe='true')
 
 
 class AmazonSESTrackingWebhookView(AmazonSESBaseWebhookView):
diff --git a/tests/test_amazon_ses_webhooks.py b/tests/test_amazon_ses_webhooks.py
index 74d029a..d0eb5f9 100644
--- a/tests/test_amazon_ses_webhooks.py
+++ b/tests/test_amazon_ses_webhooks.py
@@ -441,7 +441,7 @@ class AmazonSESSubscriptionManagementTests(WebhookTestCase, AmazonSESWebhookTest
         response = self.post_from_sns('/anymail/amazon_ses/tracking/', self.SNS_SUBSCRIPTION_CONFIRMATION)
         self.assertEqual(response.status_code, 200)
         # auto-confirmed:
-        self.mock_client.assert_called_once_with('sns', config=ANY)
+        self.mock_client.assert_called_once_with('sns', config=ANY, region_name="us-west-2")
         self.mock_client_instance.confirm_subscription.assert_called_once_with(
             TopicArn="arn:aws:sns:us-west-2:123456789012:SES_Notifications",
             Token="EXAMPLE_TOKEN", AuthenticateOnUnsubscribe="true")
@@ -469,6 +469,13 @@ class AmazonSESSubscriptionManagementTests(WebhookTestCase, AmazonSESWebhookTest
         self.assertEqual(self.tracking_handler.call_count, 0)
         self.assertEqual(self.inbound_handler.call_count, 0)
 
+    @override_settings(ANYMAIL_AMAZON_SES_CLIENT_PARAMS={"region_name": "us-east-1"})
+    def test_sns_subscription_confirmation_different_region(self):
+        """Anymail confirms the subscription in the SNS Topic's own region, rather than any default region"""
+        # (The SNS_SUBSCRIPTION_CONFIRMATION above has a TopicArn in region us-west-2)
+        self.post_from_sns('/anymail/amazon_ses/tracking/', self.SNS_SUBSCRIPTION_CONFIRMATION)
+        self.mock_client.assert_called_once_with('sns', config=ANY, region_name="us-west-2")
+
     @override_settings(ANYMAIL={})  # clear WEBHOOK_SECRET setting from base WebhookTestCase
     def test_sns_subscription_confirmation_auth_disabled(self):
         """Anymail *won't* auto-confirm SNS subscriptions if WEBHOOK_SECRET isn't in use"""