diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index f354ff0..a3d5e2e 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -33,6 +33,16 @@ Breaking changes
 *  **SendGrid:** Remove the legacy SendGrid *v2* EmailBackend
    (Anymail has defaulted to SendGrid's newer v3 API since Anymail v0.8.)
 
+Fixes
+~~~~~
+
+* Change `attach_inline_image()` default domain for *Content-ID* to "inline" (rather
+  than Python's `make_msgid()` default local hostname). This avoids problems with ESPs
+  that don't distinguish *Content-ID* from attachment filename, where a local hostname
+  ending in ".com" could cause Gmail to block messages sent with inline attachments.
+  (Mailgun, Mailjet, Mandrill and SparkPost have APIs affected by this.
+  See `#112`_ for more details.)
+
 Other
 ~~~~~
 
@@ -745,6 +755,7 @@ Features
 .. _#108: https://github.com/anymail/issues/108
 .. _#110: https://github.com/anymail/issues/110
 .. _#111: https://github.com/anymail/issues/111
+.. _#112: https://github.com/anymail/issues/112
 
 .. _@calvin: https://github.com/calvin
 .. _@joshkersey: https://github.com/joshkersey
diff --git a/anymail/message.py b/anymail/message.py
index 044e6a9..1684816 100644
--- a/anymail/message.py
+++ b/anymail/message.py
@@ -59,6 +59,10 @@ def attach_inline_image_file(message, path, subtype=None, idstring="img", domain
 
 def attach_inline_image(message, content, filename=None, subtype=None, idstring="img", domain=None):
     """Add inline image to an EmailMessage, and return its content id"""
+    if domain is None:
+        # Avoid defaulting to hostname that might end in '.com', because some ESPs
+        # use Content-ID as filename, and Gmail blocks filenames ending in '.com'.
+        domain = 'inline'  # valid domain for a msgid; will never be a real TLD
     content_id = make_msgid(idstring, domain)  # Content ID per RFC 2045 section 7 (with <...>)
     image = MIMEImage(content, subtype)
     image.add_header('Content-Disposition', 'inline', filename=filename)
diff --git a/docs/sending/anymail_additions.rst b/docs/sending/anymail_additions.rst
index 6cf5c09..05724c2 100644
--- a/docs/sending/anymail_additions.rst
+++ b/docs/sending/anymail_additions.rst
@@ -398,9 +398,15 @@ classes.)
     `idstring` and `domain` are optional, and are passed to Python's
     :func:`~email.utils.make_msgid` to generate the :mailheader:`Content-ID`.
     Generally the defaults should be fine.
-    (But be aware the default `domain` can leak your server's local hostname
-    in the resulting email.)
 
+    .. versionchanged:: 4.0
+
+        If you don't supply a `domain`, Anymail will use the simple string "inline"
+        rather than :func:`~email.utils.make_msgid`'s default local hostname. This
+        avoids a problem with ESPs that confuse :mailheader:`Content-ID` and attachment
+        filename: if your local server's hostname ends in ".com", Gmail could block
+        messages with inline attachments generated by earlier Anymail versions and sent
+        through these ESPs.
 
 .. function:: attach_inline_image(message, content, filename=None, subtype=None, idstring="img", domain=None)
 
diff --git a/tests/test_message.py b/tests/test_message.py
new file mode 100644
index 0000000..b82313c
--- /dev/null
+++ b/tests/test_message.py
@@ -0,0 +1,31 @@
+from django.core.mail import EmailMultiAlternatives
+from django.test import SimpleTestCase
+from mock import patch
+
+from anymail.message import attach_inline_image
+
+from .utils import AnymailTestMixin, sample_image_content
+
+
+class InlineImageTests(AnymailTestMixin, SimpleTestCase):
+    def setUp(self):
+        self.message = EmailMultiAlternatives()
+        super(InlineImageTests, self).setUp()
+
+    @patch("email.utils.socket.getfqdn")
+    def test_default_domain(self, mock_getfqdn):
+        """The default Content-ID domain should *not* use local hostname"""
+        # (This avoids problems with ESPs that re-use Content-ID as attachment
+        # filename: if the local hostname ends in ".com", you can end up with
+        # an inline attachment filename that causes Gmail to reject the message.)
+        mock_getfqdn.return_value = "server.example.com"
+        cid = attach_inline_image(self.message, sample_image_content())
+        self.assertRegex(cid, r"[\w.]+@inline",
+                         "Content-ID should be a valid Message-ID, "
+                         "but _not_ @server.example.com")
+
+    def test_domain_override(self):
+        cid = attach_inline_image(self.message, sample_image_content(),
+                                  domain="example.org")
+        self.assertRegex(cid, r"[\w.]+@example\.org",
+                         "Content-ID should be a valid Message-ID @example.org")